Finish the game's final secret.
Kill Mom's Heart 8 times.
Kill Isaac with Isaac.
Kill Satan with Isaac.
Kill Isaac with The Lost.
Kill Satan with The Lost.
Kill Isaac with Maggy.
Kill Satan with Maggy.
Kill Isaac with Cain.
Kill Satan with Cain.
Have 7 or more max red hearts at one time.
Kill Isaac with Judas.
Kill Satan with Judas.
Kill Isaac with Eve.
Kill Satan with Eve.
Kill Isaac with Samson.
Kill Satan with Samson.
Make 3 deals with the devil in one run.
Kill Isaac with Azazel.
Kill Satan with Azazel.
Kill Isaac with Lazarus.
Hold 55 or more pennies at one time.
Kill Satan with Lazarus.
Beat the Womb for the first time,
Kill Isaac with Eden.
Kill Satan with Eden.
Beat the Basement 40 times.
Beat the Caves 30 times.
Beat the Depths 20 times.
Beat the Basement/Cellar without taking damage.
Beat the Caves/Catacombs without taking damage.
Beat the Depths/Necropolis without taking damage.
Kill Satan
Beat the Womb/Utero without taking damage.
Beat the Chest or Dark Room without taking damage.
Beat all 20 Challenges.
Beat the Boss Rush.
Beat the Dark Room.
Beat the Chest.
Beat the Dark Room with Isaac.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Kill Mom using the Bible.
Kill Mom's Heart 5 times.
Kill Mom.
Kill Mom's Heart 9 times.
Kill Mom's Heart 10 times.
Kill Mom's Heart 11 times.
Kill Satan with ???.
Kill all 7 sins.
Beat Cathedral 5 times.
Beat Sheol 5 times.
You are the best!
Collect all items and unlock all secrets and endings.
100% the game!
Beat 2 levels in a row without taking damage.
Beat Greed Mode with Azazel
Kill ??? with Lilith
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Unlocked a new area
Beat Delirium
Just Stop!
Beat 2 levels in a row without picking up any hearts.
Kill Mega Satan
Donate 500 coins to the Greed Machine
Kill The Lamb
Uncover some lost remains..
Have 4 or more soul hearts at one time
Kill Mom's Heart 3 times.
